![]() FFP can be used when Prothrombinex-VF is unavailable. FFP is not routinely needed in combination with Prothrombinex-VF. It contains factors II, IX, X and low levels of factor VII. Prothrombinex-VF is the only PCC routinely used for warfarin reversal in Australia and New Zealand. ![]() When oral vitamin K 1 is used for this purpose, the injectable formulation, which can be given orally or intravenously, is preferred.įor immediate reversal, prothrombin complex concentrates (PCC) are preferred over fresh frozen plasma (FFP). Vitamin K 1 can be given to reverse the anticoagulant effect of warfarin. ![]() Risk factors for bleeding with warfarin use include increasing age, history of bleeding and specific comorbidities.įor patients with elevated INR (4.5–10.0), no bleeding and no high risk of bleeding, withholding warfarin with careful subsequent monitoring seems safe. For mechanical mitral valve or combined mitral and aortic valves, the target INR is 2.5–3.5. Statistics,epidemiology and research designįor most warfarin indications, the target international normalised ratio (INR) is 2.0–3.0 (venous thromboembolism and single mechanical heart valve excluding mitral).Statistics, epidemiology and research design.
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